cowboy me, 2.0: jose nazario beauty and the street

Four short links: 18 August 2013

bedford stuyvesant brooklyn, William Carleton, Wall Street estimates, wakeboard boat

Reshaping New York - Interactive Feature - -- In spite of a recession and foreclosure crisis, the mayor presided over a boom in residential construction, encompassing everything from new aeries for the rich in Manhattan to disappearing vacant lots in the South Bronx. New York has added 40,000 new buildings since he took office, and the census counted an additional 170,000 housing units in 2010, up from 10 years earlier, more than any other city. Whether the luxury high-rises of Williamsburg are good or bad for the city is a matter of continuing debate among city politicians and residents, and is even a plot line in the HBO series Girls.

AngelList Tells SEC New Fundraising Rules Will Kill Startups | TechCrunch -- Startups could face a death sentence one year ban from fundraising if they violate awkward new general solicitation fundraising rules, AngelList co-founder Naval Ravikant wrote in a letter to the SEC this week. Startups likely cant afford expensive legal counsel to help them avoid breaking the rules, yet the very severe penalty for non-compliance (not fundraising for a year) is a death penalty for a not-yet-profitable business.

How LinkedIn Became A Wall Street Juggernaut | TechCrunch -- LinkedIn has played Wall Street perfectly. Wall Street investors love a large, addressable market, and while they dont love when companies spread themselves too thin by going after many disconnected markets, they do love adjacent markets that leverage core assets. LinkedIn has done incredibly well at building multiple revenue streams (Talent Solutions, Marketing Solutions and Premium Subscriptions are all rapid growers that contribute a healthy share of overall revenue), increasing their product set, and moving to mobile with an aggressive iOS plus HTML5 strategy, all leveraging their core data set.

Has Carl June Found a Key to Fighting Cancer? | Philadelphia magazine -- Ah, theres no cure for what I have, Walt mumbled, and went back to work. Carl June had an idea for a new kind of cancer treatment involving T cells, those building blocks of the immune system. A few researchersfirst an Israeli named Zelig Eshhar in the 80s, then other investigators around the worldhad discovered that you could force a T cell to stick to a tumor cell and kill it. What if, instead of replacing a patients immune system (as in a bone-marrow transplant) or pumping him full of poison (chemo), you could just borrow some cells, tweak them, and infuse them back into the patient? You could snap a new piece on the end, like a LEGO, that fit into a molecule on the surface of a breast-cancer cell, or a pancreatic-cancer cell, or whatever kind of cancer you wanted to attack. But June wondered if the cells could work in cancer. Together, the men decided to work toward a test of engineered T cells in patients suffering from a certain family of leukemias, including chronic lymphocytic leukemia. By 2006 and 2007, teams at other universities had run their own trials of engineered T cells in cancer patients. They injected their custom T cells into mice that had been genetically modified to accept human cells. By 2007, after testing several varieties of cells, Milone had identified one that seemed to work best, and was able to show that it could cure leukemia in mice. The T cells then traveled to Levines Clinical Cell and Vaccine Production Facility, which was full of biosafety cabinets and scales and flasks, and refrigerators named after characters from The Simpsons: the Otto Fridge and the Maggie Fridge, along with the Krusty Freezer. Levine and his technicians added the magnetic beads and the vector to Ludwigs T cells and put the cells in a nutrient medium that provided everything they needed to divide and grow. Porter and June hoped that tumor lysis was the cause of Ludwigs fevers, because if it was, it meant that the T cells were working; Theyd been either torn to shreds directly by T cells that acted like serial killers, moving from one tumor cell to the next, slashing membranes and spilling innards, or theyd been destroyed by enzymes secreted by the T cells. The Penn trial was definitely a turning point, says Michel Sadelain, a researcher at Memorial Sloan-Kettering Cancer Center who has made important contributions to the study of engineered T cells. Walt wasnt good with computers, so his eldest sister, Nancy Nelson, a woman in her early 60s with dirty-blond hair and glasses, filled out the form and hit SEND. Nancy had already decided that if Walt got into the trial, she would leave California to be at his side for however long it took. She set up an appointment for Walt to meet Porter. If you let me into the trial, Walt told Porter, I promise Ill be the best patient youve ever had. It also boded well that Nancy was here, wearing a silver necklace that said CURE WALT. After Emma received her dose of T cells, her bodys immune system had revved up, releasing cytokines that caused fever, nausea, hypoxia (low oxygen) and low blood pressure. Walt finally received his infusion of T cells on Tuesday, May 15th. Chelle couldnt be there, so she texted Nancy a prayer to read out loud:

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